Prenatal Diagnosis using Fetal Genetic Material in Maternal Circulation
نویسندگان
چکیده
منابع مشابه
Prenatal Diagnosis Using Fetal Genetic Material in Maternal Circulation
In the second half of the 20 century, the prenatal diagnosis armamentarium changed dramatically with the introduction of amniocentesis and chorionic villus sampling. Both modalities are, however, invasive techniques and carry a certain risk, albeit low (0.5–1%), of pregnancy loss [1]. Routine noninvasive methods of prenatal diagnosis include firstand second-trimester ultrasonography and materna...
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Since the existence of cell-free fetal DNA (cff-DNA) in maternal circulation was discovered, it has been identified as a promising source of fetal genetic material in the development of reliable methods for non-invasive prenatal diagnosis (NIPD) of fetal trisomy 21 (T21). Currently, a prenatal diagnosis of fetal T21 is achieved through invasive techniques, such as chorionic villus sampling or a...
متن کاملNon-invasive prenatal testing using cell-free fetal DNA in maternal circulation.
The identification of cell-free fetal DNA (cffDNA) in maternal circulation has made non-invasive prenatal testing (NIPT) possible. Maternal plasma cell free DNA is a mixture of maternal and fetal DNA, of which, fetal DNA represents a minor population in maternal plasma. Therefore, methods with high sensitivity and precision are required to detect and differentiate fetal DNA from the large backg...
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Introduction Encephalomalacia in a developing fetus is a rare and devastating neurological finding on radiologic imaging. Maternal diabetic ketoacidosis (DKA) can lead to metabolic and vascular derangements which can cause fetal encephalomalacia. Case We report the case of a 27-year-old pregnant woman with White's Class C diabetes mellitus who presented in the 25th week of gestation with DKA. F...
متن کاملCulture of fetal cells from maternal blood for prenatal diagnosis.
The isolation and analysis of fetal cells from maternal blood would allow non-invasive prenatal genetic screening and diagnosis. Over the past decade, progress has been made towards this goal using various enrichment strategies and analysis by fluorescence in-situ hybridization with chromosome-specific probes and PCR. One method that is currently being explored involves culturing fetal cells. D...
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ژورنال
عنوان ژورنال: Taiwanese Journal of Obstetrics and Gynecology
سال: 2005
ISSN: 1028-4559
DOI: 10.1016/s1028-4559(09)60100-5